The key circulating metabolite of ketamine (norketamine) shown action at the same receptor with fewer affinity. Norketamine is about 1/3 as Energetic as ketamine in cutting down halothane needs (MAC) on the rat. The FDA has warned that ketamine and compounded ketamine solutions aren’t approved to treat any psychiatric disorder. https://wildbookmarks.com/story18300279/5-essential-elements-for-ketamine-nasal-spray